 |
Navigated Gamma Probe Reconstruction for Sentinel Lymph Node LocalizationProject duration: 2006/01/01 - 2010/12/31In industrial collaboration with: Dr. Farhad Daghighian, President, IntraMedical Imaging LLC, Los Angeles, CA, USA In medical collaboration with: PD Dr. Andreas Buck, Oberarzt, Nuklearmedicine, Klinikum rechts der Isar, TUM, Munich, Germany PD Dr. Stefan Paepke, Leitender Oberarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Moritz Hamann, Assistentarzt, Gynaecology, Klinikum rechts der Isar, TUM, Munich, Germany Prof. Dr. Jürgen Becker, Oberarzt, Dermatology, Hautklinik , Universität Würzburg, Munich, Germany Scientific Director: Nassir Navab Contact Person: Thomas Wendler |
Abstract
Nuclear medicine imaging modalities assist commonly in surgical guidance given their functional nature. However, when used in the operating room they present limitations. Pre-operative tomographic 3D imaging can only serve as a vague guidance intra-operatively, due to movement, deformation and changes in anatomy since the time of imaging, while standard intra-operative nuclear measurements are limited to 1D or (in some cases) 2D images with no depth information. To resolve this problem we propose the synchronized acquisition of position, orientation and readings of gamma probes intra-operatively to reconstruct a 3D activity volume. In contrast to conventional emission tomography, here, in a first proof-of-concept, the reconstruction succeeds without requiring symmetry in the positions and angles of acquisition, which allows greater flexibility and thus opens doors towards 3D intra-operative nuclear imaging.Publications
| 2008 | |
| T. Wendler, T. Lasser, A. Buck, C. Özgür, M. Schwaiger, S. Ziegler, N. Navab
First in Vivo Use of a Fused Gamma Ultrasound System Proceedings of RSNA 2008, Chicago, USA, December 2008 (bib) |
|
| T. Wendler, T. Lasser, S. Ziegler, N. Navab
Towards Confident 3D Tomographic Reconstruction for Asymmetric, Sparse Detector Geometries Proceedings of IEEE Medical Imaging Conference (IEEE MIC 2008), Dresden, Germany, October 2008 (bib) |
|
| T. Lasser, T. Wendler, S. Ziegler, N. Navab
Towards Reproducibility of Freehand 3D Tomographic Nuclear Imaging Proceedings of IEEE Medical Imaging Conference (IEEE MIC 2008), Dresden, Germany, October 2008 (bib) |
|
| T. Lasser, T. Wendler, J. Traub, S. Ziegler, N. Navab
Definition of optimal collimator geometries for 3D tomographic thyroid scintigraphy using navigated gamma probes Proceedings of Annual Congress of the European Association of Nuclear Medicine (EANM 2008), Munich, Germany, October 2008 (bib) |
|
| T. Wendler, T. Lasser, A. Buck, J. Traub, M. Schwaiger, S. Ziegler, N. Navab
First case report of 3D tomographic thyroid scintigraphy with tracked gamma probes Proceedings of Annual Congress of the European Association of Nuclear Medicine (EANM 2008), Munich, Germany, October 2008 (bib) |
|
| T. Wendler, J. Traub, T. Lasser, M. Feuerstein, J. Vogel, S. Ziegler, N. Navab
Combined ultrasound and gamma probe imaging for examination of thyroid nodules Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib) |
|
| T. Wendler, A. Hartl, T. Lasser, J. Traub, S. Ziegler, N. Navab
3D Intra-operative nuclear imaging for SLNB in neck Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib) |
|
| N. Navab, J. Traub, A. Buck, S. Ziegler, T. Wendler
Navigated nuclear probes for intra-operative functional imaging Proceedings of 5th IEEE International Symposium on Biomedical Imaging (ISBI 2008), Paris, France, May 14 - 17 2008 (to appear) (bib) |
|
| 2007 | |
|
T. Wendler, M. Feuerstein, J. Traub, T. Lasser, J. Vogel, F. Daghighian, S. Ziegler, N. Navab
Real-time fusion of ultrasound and gamma probe for navigated localization of liver metastases Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 29 - November 2007, LNCS 4792 (2), pp. 909-917 (bib) |
|
|
T. Wendler, A. Hartl, T. Lasser, J. Traub, F. Daghighian, S. Ziegler, N. Navab
Towards intra-operative 3D nuclear imaging: reconstruction of 3D radioactive distributions using tracked gamma probes Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 29 - November 2 2007, LCNS 4792 (2), pp. 252-260 (bib) |
|
|
T. Wendler, J. Traub, A. Hartl, T. Lasser, M. Burian, A. Buck, F. Daghighian, M. Schwaiger, S. Ziegler, N. Navab
Adding navigation to radio-guided surgery: new possibilities, new problems, new solutions Proceedings of Russian Bavarian Conference on Biomedical Engineering (RBC Biomed 2007), Erlangen, Germany, July 2-3, 2007, pp. 96-100 (bib) |
|
T. Wendler, A. Hartl, J. Traub, S. Ziegler, N. Navab
Intraoperative nuclear imaging using navigated gamma-probes for tumor localization Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2007), Washington D.C., USA, June 2007 (bib) |
Clinical Relevance
This project aims currently at applications in breast cancer and melanoma and in particular as assistance in sentinel lymph node biopsy (SLNB). The incidence of these cancer types in 2004 was 124 and 19,6 per 100.000 in the US. The mortality is 24 and 2,6 respectively. SLNB using lymphatic mapping and gamma-probes is part of current state-of-art staging modality in both this cancer types for tumors of grade T2 and T3, but also TX (app. half of the cases). A precise localization of these nodes is not necessary easy in regions with many nodes. The biopsy of a wrong node may imply a wrong prognosis and thus can play a fundamental role in the treatment. In breast the rate of success in localization is in average 89% but varies from 41% to 100%. This is not that dramatic in melanoma, however represents still a relevant problem when aiming at a conservative procedure. The introduced system allows a secure localization without changing the workflow and can be a great assistance and a clear improvement in effectiveness of the treatment.Team
Contact Person
|
Working Group
|
|
|
|
|
|
|
|
Alumni
|
|
|
Location
 |
Klinikum rechts der Isar der Technischen Universitüt München Ismaninger Str. 22 81675 München IFL Lab - Room: 01.3a-c Tel.: +49 89 4140-6457 Fax: +49 89 4140-6458 |
 |
internal project page
Please contact Thomas Wendler for available student projects within this research project.
