Navigated Beta Probes for Optimal Tumor Resection Project duration: 2005/02/01 - 2010/12/31 In industrial collaboration with: Dr. Farhad Daghighian, President, IntraMedical Imaging LLC, Los Angeles, CA, USA In medical collaboration with: PD Dr. Andreas Buck, Oberarzt, Nuclear Medicine, Klinikum rechts der Isar, TUM, Munich, Germany Dr. Maria Burian, Assistentarzt, Surgery, Klinikum rechts der Isar, TUM, Munich, Germany Contact Person: Thomas Wendler

Keywords: Medical Imaging, Molecular Imaging, Computer-Aided Surgery, Medical Augmented Reality

Abstract

In minimally invasive tumor resection, the goal is to perform a minimal but complete removal of cancerous cells. In the last decades interventional beta probes supported the detection of remaining tumor cells. However, scanning the patient with an intraoperative probe and applying the treatment are not done simultaneously. The main contribution of this work is to extend the one dimensional signal of a nuclear probe to a four dimensional signal including the spatial information of the distal end of the probe. This signal can be then used to guide the surgeon in the resection of residual tissue and thus increase its spatial accuracy while allowing minimal impact on the patient.

Publications

2008
	T. Wendler, A. Hartl, T. Lasser, J. Traub, S. Ziegler, N. Navab Tracking-based statistical correction for radio-guided cancer surgery Proceedings of World Molecular Imaging Congress (WMIC 2008), Nice, France, September 2008 (bib)
	A. Hartl, T. Wendler, J. Traub, T. Lasser, S. Ziegler, N. Navab Confident radioactivity surface reconstruction for control of resection borders Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2008), New Orleans, USA, June 2008 (bib)
	N. Navab, J. Traub, A. Buck, S. Ziegler, T. Wendler Navigated nuclear probes for intra-operative functional imaging Proceedings of 5th IEEE International Symposium on Biomedical Imaging (ISBI 2008), Paris, France, May 14 - 17 2008 (to appear) (bib)
2007
	N. Navab, J. Traub, T. Sielhorst, M. Feuerstein, C. Bichlmeier Action- and Workflow-Driven Augmented Reality for Computer-Aided Medical Procedures IEEE Computer Graphics and Applications, vol. 27, no. 5, pp. 10-14, Sept/Oct, 2007 (bib)
	T. Wendler, J. Traub, A. Hartl, T. Lasser, M. Burian, A. Buck, F. Daghighian, M. Schwaiger, S. Ziegler, N. Navab Adding navigation to radio-guided surgery: new possibilities, new problems, new solutions Proceedings of Russian Bavarian Conference on Biomedical Engineering (RBC Biomed 2007), Erlangen, Germany, July 2-3, 2007, pp. 96-100 (bib)
	T. Wendler, J. Traub, S. Ziegler, N. Navab Validation of navigated beta-probe imaging with PET/CT-generated activity surfaces. New approach in radio-guided resection for FDG-positive tumors Proceedings of Annual Meeting of Society of Nuclear Medicine (SNM 2007), Washington D.C., USA, June 2007 (bib)
	O. Kishenkov, T. Wendler, J. Traub, S. Ziegler, N. Navab Method for projecting functional 3D information onto anatomic surfaces: Accuracy improvement for navigated 3D beta-probes Proceedings of Bildverarbeitung fuer die Medizin (BVM 2007), Munich, Germany, March 2007, pp.66-70 (bib)
2006
	T. Wendler, J. Traub, S. Ziegler, N. Navab Navigated three dimensional beta probe for optimal cancer resection Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 1-6 2006, LNCS 4190 (1), pp. 565-569 (bib)

Clinical Relevance

In 2007 37.000 new cases of pancreatic cancer are expected in the US. 33.000 Americans will die of that cancer this year. In the case of primary liver cancer this numbers are 19.000 and 17.000. Liver metastases will be found in up to 70% of all 559.000 expected cancer deaths in 2007 in the US. 20% of all pancreas cases will undergo resection with an expected local recurrence rate of 30%. For liver 1/3 of the patients with primary tumor or metastasis will be selected for resection with a local recurrence rate of also 30%. The system proposed aims at improving these rates by an enhanced intra-operative border control using beta-probes. Any improvement here will mean a big step towards a more effective, but still less invasive cancer surgery.

Team

Contact Person

Thomas Wendler

Working Group

Abtin Rasoulian

Alexander Hartl

Andreas Buck

Irene Faure de Pebeyre

Nassir Navab

Sibylle Ziegler

Tobias Lasser

Alumni

Ali Bigdelou

Berenika Zaraska

Joerg Traub

Oleg Kishenkov

Location

Klinikum rechts der Isar der Technischen Universitüt München Ismaninger Str. 22 81675 München IFL Lab - Room: 01.3a-c Tel.: +49 89 4140-6457 Fax: +49 89 4140-6458

Visit our lab at Klinikum rechts der Isar.



internal project page

Please contact Thomas Wendler for available student projects within this research project.